Best Option:

Harrisburg International Airport (MDT)
11 miles to Downtown Harrisburg

Many Harrisburg hotels offer shuttles to and from HIA, including:

• Hilton Harrisburg - $12 / person one way; runs by appointment only
  
• Crowne Plaza Harrisburg

Other hotels may offer shuttles.  Contact them directly for more information.  

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Other Options:

Philadelphia International Airport (PHI)
100 miles from downtown Harrisburg

Baltimore/Washington International (BWI)
90 miles from downtown Harrisburg

* See Susie's Wedding Blog for further travel tips.